Craig Kilborn leaving his late night gig thinking he would be the next big comic actor
Halle Berry doing Catwoman
Katie Holmes not coming back for the Dark Knight
Also there are too many to name, but actors on TV that leave a successful show (ex: the guy who played Lex on Smallville) and have shyt to show for it. You can even argue the other way, Tom Welling being on that show too long and where is he now
EDIT: Forgot about this one, add this to the FML Hall of Fame....Dougray Scott was chosen to be Wolverine, but did Mission Impossible II instead
