Best Friendships in Movies/TV

[MartyMcFly]

Doc and Wyatt

 

[YOLO_JONES]

Keenan & Kel

Ricardos & Mertz

 

[JoseLuisGotcha]

Michael Knight and KITT

 

[Copy Ninja]

Gon/Killua

 

[Sccit]

4 PAGES IN AND I DONT SEE

RED AND METH

 

[E R 11 C]

Ron Burgundy & Baxter
Choji & Shikamaru
Vincent Chase & Eric Murphy
Seth & Evan
Goku & Krillin
Ren & Stimpy
Bevis & Butthead
Michael Scott & Dwight Shrute
Chandler & Joey
Doug & Skeeter

 

[Rakim Allah]

TV

Will and Jazz and Will and Carlton became one.
Marcus and Mo
Gus and Shawn
JD and Turk
Arnold and Dudley
Dwayne and Ron
Theo and Cockroach
Bart and Millhouse
Al and Jefferson
Charles and Buddy Lembeck
Vince and E
Turtle and Drama
Pam and Gina
George and Tom Willis(later seasons)
Norm and Cliff
L Train and Al
Jamal and Chris
Raven, Eddie and Chelsea
Bodie and Poot

*Edit*
How could I forget Daffy and Bugs from the The Looney Tunes Show (2011)

 

[Deltron]

TV

Will and Jazz and Will and Carlton became one.
Marcus and Mo
Gus and Shawn
JD and Turk
Arnold and Dudley
Dwayne and Ron
Theo and Cockroach
Bart and Millhouse
Al and Jefferson
Charles and Buddy Lembeck
Vince and E
Turtle and Drama
Pam and Gina
George and Tom Willis(later seasons)
Norm and Cliff
L Train and Al
Jamal and Chris
Raven, Eddie and Chelsea
Bodie and Poot

city guys drop

 

[ZILFIN]

Kenan & Kel
Tommy Gavin & Lou
Marlon & Shawn (Brothers, but still they were the best best-friends)
Brian & Dom
Brian & Roman

 

[ThaRealness]

Michael Corleone and Hyman Roth