Running a game and a game within an emulator is two different things. As for the mouse problem,
I don't know how it's like on the mac but I had my controls set up for Mario Galaxy with a 360 controller but it ain't really work. The aiming was hard to use with an analog stick. Best thing is get a blutooth adapter for your mac or if it already has one and sync a real Wiimote to it if you can.
