I feel you, im not too concerned about the story like you said they can make some shyt up plus the ending of 5 was very opened.
My main concern is the gameplay especially since itsuno left. He made the series what it is now from the plot to incorporating style switching to Nero and his devil bringer gameplay.
There is just sohh much that he brought to the series and im not sure Capcom has someone that can do what he did which is evolve the gameplay while not fukk up the legacy of DMC like whoever was making DMC2.
I doubt Capcom will have another DMC2 incident.