Never gonna happen. Let's not forget how 50 Cent thinks. He doesn't just diss his enemies, he attempts to slaughter them. He personally invested time in ruining Buck's career/life due to his disloyalty to G Unit. He hasn't fukked with Banks despite the tension because there's still mutual respect/love there. But Game? Nah b, 50 WILL NOT contribute to feeding that nikka ever again. Who benefits more from a reunion, ask yourselves that. The answer is Game: his last album flopped, nobody is asking him for guest verses, etc. So in 50's mind, a reunion would simply be helping Game; it's not like 50 needs any money or exposure right now, even though he's nearly as culturally irrelevant as Game is right now.
If Dre and Iovinne couldn't bring these dudes back together back when they were hot and could have sold tons of records, why yall think it'll happen now?