Yeah, there really is no "best work" with him. If you dig him, you'll enjoy most of if not all his stuff.
The Leak Edition vol. 1 & 2 are good jumping off points.
The jount with Lewis Parker is absolute crack
The jazz era album was a cool listen with j Rawls
I am not for sale has a crazy flying lotus track
The doom album
The scienz of life stuff is a little nerdy though.