What you resist persists.
Ex. Some people want a great relationship but they hold on to this struggling relationship trying to make it work, or remain heartbroken when God/the Universe wants you to let go to make room for something even better.
Same with a career that doesn't serve you. You hate your job but continue to work hard for a promotion you really want, instead you get passed up for the promotion and laid off and start applying for a new job, your new job is even better. You needed to let go of your old job to make room for something better.
Or you are consistently worried about your kids that you shelter them, restrict them and do everything for them. But if you let go and allow your kids to make their own mistakes,they will learn to pick themselves up and be self-sufficient.