It's a solid twin stick shooter that's VERY addictive if you're into that sort of shyt and it hosts a healthy amount of powerups that alter the way you shoot tears (Bullets), interact with the environment and enemies and just move through the levels overall.
While I never really got down on the first one (Essentially The Binding of Isaac series is ONE game but there are like two different versions, the old one, a newer one that's enhanced with cleaner, more fluid art, music etc that got propped up with like 2 massive DLC expansions) like that, by the time the second, revamped version of it came out, I played and was fukking HOOKED.
As
@Kamikaze Revy said, the story and the whole religious content might turn you off if you against that sort of shyt, but that shyt really takes a backseat to the type of character you build throughout your run with the powerups you gain and the attributes you increase (Or decrease by trickery) which helps you later on as the rooms get tougher and you start to meet end game bosses (Mother/Satan/Mega Satan/The Lamb etc..)
It's one of those games where you WILL die alot and often more than you'd complete a game (Reaching the end boss based on choices/options you chose/initiated) but you still play 'cause it's fun, especially when you get a nice cadre of familiars (sidekicks that shoot/protect you) or you're all hopped up on powers and you're just crushing shyt until you finally break on through or die in the process.
Game's fun as fukk and it's my most played game on Steam. I prolly got about 150+ hours in it. Music is dope and you can't help but feel for little breh in those damned cutscenes.
