Table 1 provides the details of each study included in this analysis. Ten were from the US, and 17 countries were represented. We observed a marked age-related increase in the prevalence of incidental prostate cancer discovered at autopsy (Table 2), with a prevalence of 47.3% among US White and European men aged 80+. These findings are provided in graphical form in Figures 1--3.3. These data underestimate the true cumulative incidence of total prostate cancer because they do not include clinically diagnosed cases. The number of diagnosed cancers with low-risk features, though substantial, is therefore small compared to the millions of undiagnosed cases. Projected to the current age and racial distribution, these data suggest roughly 45 million cases of potentially detectable prostate cancer in the US. By contrast, an estimated 2.9 million US men are living with a prostate cancer diagnosis31.
scary.
The High Prevalence of Undiagnosed Prostate Cancer at Autopsy: Implications for Epidemiology and Treatment of Prostate Cancer in the Prostate-Specific Antigen-Era