When he is referencing people hating on him for speaking on Pac, the biggest news piece in that regard was this tweet.
So it's logical to assume he's talking about that backlash, since he has not spoken negatively against the movie at all. Game and him are fully supporting it.
The instance he is referencing in regards to 50, is him talking about how shytty he thought the movie was, which disrespects the makers, not the subject.
hustlemania you comprehend?