It's very complicated. Gene therapy alone won't open up the growth plates for adults. Although, I suppose advances in stem cell research to regenerate growth plates could allow for that as well as ensuring the entire body grows proportionately.
thats sounds promising
this seems like a promising area of research that AI can help advance is discovery models get better.
The growth plate (GP) is a cartilaginous region situated between the epiphysis and metaphysis at the end of the immature long bone, which is susceptible to mechanical damage because of its vulnerable structure. Due to the limited regeneration ...
pmc.ncbi.nlm.nih.gov
Enlightenment of Growth Plate Regeneration Based on Cartilage Repair Theory: A Review
Xianggang Wang 1,2,†,
Zuhao Li 1,2,†,
Chenyu Wang 3,
Haotian Bai 1,2,
Zhonghan Wang 1,2,
Yuzhe Liu 1,2,
Yirui Bao 4,
Ming Ren 1,2,*,
He Liu 1,2,*,
Jincheng Wang 1,2,*
PMCID: PMC8209549 PMID:
34150725
Abstract
The growth plate (GP) is a cartilaginous region situated between the epiphysis and metaphysis at the end of the immature long bone, which is susceptible to mechanical damage because of its vulnerable structure. Due to the limited regeneration ability of the GP, current clinical treatment strategies (e.g., bone bridge resection and fat engraftment) always result in bone bridge formation, which will cause length discrepancy and angular deformity, thus making satisfactory outcomes difficult to achieve. The introduction of cartilage repair theory and cartilage tissue engineering technology may encourage novel therapeutic approaches for GP repair using tissue engineered GPs, including biocompatible scaffolds incorporated with appropriate seed cells and growth factors. In this review, we summarize the physiological structure of GPs, the pathological process, and repair phases of GP injuries, placing greater emphasis on advanced tissue engineering strategies for GP repair. Furthermore, we also propose that three-dimensional printing technology will play a significant role in this field in the future given its advantage of bionic replication of complex structures. We predict that tissue engineering strategies will offer a significant alternative to the management of GP injuries.
Keywords: growth plate, cartilage tissue engineering, scaffold, bone marrow mesenchymal stem cells, three-dimensional printing
The repair of growth plate injuries is a highly complex process that involves precise spatiotemporal regulation of multiple cell types. While significant progress has been made in understanding the pathological mechanisms underlying growth plate ...
pmc.ncbi.nlm.nih.gov