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C L O N E*0690//////
real miracles take time*
Artificial spinal cords are now a thing
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Ezekiel 25:17
Veteran
We need to work on aging better. Don't get me wrong, curing ailments and having longer life expectancy is great, but just how agile are you at 90?
But with a slower aging process, If I was 90 but had the body of a 30 year old I'd be content.
This is what science is about.
Source : Rats walk again after breakthrough spinal cord repair with 3D printing
Science News
from research organizations
The method involves creating a unique 3D-printed framework for lab-grown organs, called an organoid scaffold, with microscopic channels. Credit: McAlpine Research Group, University of Minnesota
For the first time, a research team at the University of Minnesota Twin Cities demonstrated a groundbreaking process that combines 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery.
The study was recently published in Advanced Healthcare Materials, a peer-reviewed scientific journal.
According to the National Spinal Cord Injury Statistical Center, more than 300,000 people in the United States suffer from spinal cord injuries, yet there is no way to completely reverse the damage and paralysis from the injury. A major challenge is the death of nerve cells and the inability for nerve fibers to regrow across the injury site. This new research tackles this problem head-on.
The method involves creating a unique 3D-printed framework for lab-grown organs, called an organoid scaffold, with microscopic channels. These channels are then populated with regionally specific spinal neural progenitor cells (sNPCs), which are cells derived from human adult stem cells that have the capacity to divide and differentiate into specific types of mature cells.
"We use the 3D printed channels of the scaffold to direct the growth of the stem cells, which ensures the new nerve fibers grow in the desired way," said Guebum Han, a former University of Minnesota mechanical engineering postdoctoral researcher and first author on the paper who currently works at Intel Corporation. "This method creates a relay system that when placed in the spinal cord bypasses the damaged area."
In their study, the researchers transplanted these scaffolds into rats with spinal cords that were completely severed. The cells successfully differentiated into neurons and extended their nerve fibers in both directions -- rostral (toward the head) and caudal (toward the tail) -- to form new connections with the host's existing nerve circuits.
The new nerve cells integrated seamlessly into the host spinal cord tissue over time, leading to significant functional recovery in the rats.
"Regenerative medicine has brought about a new era in spinal cord injury research," said Ann Parr, professor of neurosurgery at the University of Minnesota. "Our laboratory is excited to explore the future potential of our 'mini spinal cords' for clinical translation."
While the research is in its beginning stages, it offers a new avenue of hope for those with spinal cord injuries. The team hopes to scale up production and continue developing this combination of technologies for future clinical applications.
In addition to Han and Parr, the team included Hyunjun Kim and Michael McAlpine from the University of Minnesota Department of Mechanical Engineering; Nicolas S. Lavoie, Nandadevi Patil and Olivia G. Korenfeld from the University of Minnesota Department of Neurosurgery; Manuel Esguerra from the University of Minnesota Department of Neuroscience; and Daeha Joung from the Department of Physics at Virginia Commonwealth University.
This work was funded by the National Institutes of Health, the State of Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant Program and the Spinal Cord Society.
Read the full paper entitled, "3D-Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury" on the Advanced Healthcare Materials website.
Story Source:
Materials provided by University of Minnesota. Note: Content may be edited for style and length.
Journal Reference:
Cite This Page:
University of Minnesota. "Rats walk again after breakthrough spinal cord repair with 3D printing." ScienceDaily. ScienceDaily, 26 August 2025. <www.sciencedaily.com/releases/2025/08/250826005226.htm>.
University of Minnesota. (2025, August 26). Rats walk again after breakthrough spinal cord repair with 3D printing. ScienceDaily. Retrieved September 3, 2025 from www.sciencedaily.com/releases/2025/08/250826005226.htm
University of Minnesota. "Rats walk again after breakthrough spinal cord repair with 3D printing." ScienceDaily. www.sciencedaily.com/releases/2025/08/250826005226.htm (accessed September 3, 2025).
Science News
from research organizations
Rats walk again after breakthrough spinal cord repair with 3D printing
Scientists have pioneered a new way to help repair spinal cord injuries by combining 3D printing, stem cell technology, and lab-grown tissues.
For the first time, a research team at the University of Minnesota Twin Cities demonstrated a groundbreaking process that combines 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery.
The study was recently published in Advanced Healthcare Materials, a peer-reviewed scientific journal.
According to the National Spinal Cord Injury Statistical Center, more than 300,000 people in the United States suffer from spinal cord injuries, yet there is no way to completely reverse the damage and paralysis from the injury. A major challenge is the death of nerve cells and the inability for nerve fibers to regrow across the injury site. This new research tackles this problem head-on.
The method involves creating a unique 3D-printed framework for lab-grown organs, called an organoid scaffold, with microscopic channels. These channels are then populated with regionally specific spinal neural progenitor cells (sNPCs), which are cells derived from human adult stem cells that have the capacity to divide and differentiate into specific types of mature cells.
"We use the 3D printed channels of the scaffold to direct the growth of the stem cells, which ensures the new nerve fibers grow in the desired way," said Guebum Han, a former University of Minnesota mechanical engineering postdoctoral researcher and first author on the paper who currently works at Intel Corporation. "This method creates a relay system that when placed in the spinal cord bypasses the damaged area."
In their study, the researchers transplanted these scaffolds into rats with spinal cords that were completely severed. The cells successfully differentiated into neurons and extended their nerve fibers in both directions -- rostral (toward the head) and caudal (toward the tail) -- to form new connections with the host's existing nerve circuits.
The new nerve cells integrated seamlessly into the host spinal cord tissue over time, leading to significant functional recovery in the rats.
"Regenerative medicine has brought about a new era in spinal cord injury research," said Ann Parr, professor of neurosurgery at the University of Minnesota. "Our laboratory is excited to explore the future potential of our 'mini spinal cords' for clinical translation."
While the research is in its beginning stages, it offers a new avenue of hope for those with spinal cord injuries. The team hopes to scale up production and continue developing this combination of technologies for future clinical applications.
In addition to Han and Parr, the team included Hyunjun Kim and Michael McAlpine from the University of Minnesota Department of Mechanical Engineering; Nicolas S. Lavoie, Nandadevi Patil and Olivia G. Korenfeld from the University of Minnesota Department of Neurosurgery; Manuel Esguerra from the University of Minnesota Department of Neuroscience; and Daeha Joung from the Department of Physics at Virginia Commonwealth University.
This work was funded by the National Institutes of Health, the State of Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant Program and the Spinal Cord Society.
Read the full paper entitled, "3D-Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury" on the Advanced Healthcare Materials website.
Story Source:
Materials provided by University of Minnesota. Note: Content may be edited for style and length.
Journal Reference:
- Guebum Han, Nicolas S. Lavoie, Nandadevi Patil, Olivia G. Korenfeld, Hyunjun Kim, Manuel Esguerra, Daeha Joung, Michael C. McAlpine, Ann M. Parr. 3D‐Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury. Advanced Healthcare Materials, 2025; DOI: 10.1002/adhm.202404817
Cite This Page:
University of Minnesota. "Rats walk again after breakthrough spinal cord repair with 3D printing." ScienceDaily. ScienceDaily, 26 August 2025. <www.sciencedaily.com/releases/2025/08/250826005226.htm>.
University of Minnesota. (2025, August 26). Rats walk again after breakthrough spinal cord repair with 3D printing. ScienceDaily. Retrieved September 3, 2025 from www.sciencedaily.com/releases/2025/08/250826005226.htm
University of Minnesota. "Rats walk again after breakthrough spinal cord repair with 3D printing." ScienceDaily. www.sciencedaily.com/releases/2025/08/250826005226.htm (accessed September 3, 2025).
Givethanks
Superstar
Idk why this reminds me of AOT
How so?
Science in that series was from the stone ages.I think that planet basically discovered hot air baloons during season3
Google AI:
While no disease has been completely "cured" in the last 20 years, several diseases have been effectively eradicated or significantly reduced in incidence:
Eradicated Diseases:
Eradicated Diseases:
- Smallpox: Eradicated worldwide in 1980.
- Rinderpest: Eradicated worldwide in 2011.
- Polio: On the verge of eradication, with only a few cases remaining in a few countries.
- Measles: Nearly eliminated in many countries due to widespread vaccination.
- Malaria: Incidence has declined significantly in many parts of the world, particularly in Africa.
- Tuberculosis: Treatment and control efforts have led to a decline in cases.
- Lymphatic filariasis: Eliminated in several countries through mass drug administration programs.
- Malaria: Incidence has declined significantly in many parts of the world, particularly in Africa.
- Chickenpox: Incidence has decreased significantly since the introduction of the chickenpox vaccine.
- Tetanus: Vaccination programs have reduced cases significantly.
- Diphtheria: Also controlled through vaccination.
You are all kinda saying the same thing but missing the point. Think of aging as a disease and all of the things that come along with it are symptoms of aging. If the process of aging itself can be managed then all of the deterioration that comes from it will diminish as well. Imagine being 95 with the body and mind of a 45 year old. That is the goal.
Givethanks
Superstar
My lazy ass saw spinal cord and thought AoT lol.How so?
Science in that series was from the stone ages.I think that planet basically discovered hot air baloons during season3
I swear the world was pretty modern, was it just the Eldians of Paradise Island that were living in the stone ages lol
Side note, have you watched Code Geass?
Ezekiel 25:17
Veteran
Solve cancer isn't reducing aging.
Your skin still wrinkled. Your reflexes are still slow. Your joints are still aching.
We just gone have a bunch of 120 year olds playing chess in the park because that's all they can do.
Really excited to see how organoid tech really takes off. They already got the buzz from that neural tissue trained to playing pong. I'm thinking space stocks and organoids is gonna be the next area for the markets to look to.
god shamgod
Veteran
This is crazy , hope this advances enough for someone like Darryl Mitchell to walk again
Dude spent half his life with the ability to walk and been paralyzed since 2001
Dude spent half his life with the ability to walk and been paralyzed since 2001