Depression is likely not caused by a chemical imbalance in the brain, study says
Story at a glance Researchers from University College London conducted an umbrella review of past meta-studies and systematic analyses of depression’s relationship to serotonin. For years, a chemic…
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Depression is likely not caused by a chemical imbalance in the brain, study says
Story at a glance Researchers from University College London conducted an umbrella review of past meta-studies and systematic analyses of depression’s relationship to serotonin. For years, a chemic…

Depression is likely not caused by a chemical imbalance in the brain, study says
“Many people take antidepressants because they have been led to believe their depression has a biochemical cause, but this new research suggests this belief is not grounded in evidence.”By Joseph Guzman | July 21, 2022 | Jul
Story at a glance
- Researchers from University College London conducted an umbrella review of past meta-studies and systematic analyses of depression’s relationship to serotonin.
- For years, a chemical imbalance of serotonin has been widely viewed as the culprit for depression, resulting in the widespread use of antidepressants.
- The study published this week in the journal Molecular Psychiatry concluded that there’s “no clear evidence” that serotonin levels or serotonin activity is responsible for depression.
A recent review study is pushing back against long-held views in medicine that depression is caused by a serotonin imbalance in the brain.
Researchers from University College London conducted an umbrella review of past meta-studies and systematic analyses of depression’s relationship to serotonin activity that included tens of thousands of participants.
The study published this week in the journal Molecular Psychiatry concluded that there’s “no clear evidence” that serotonin levels or serotonin activity is responsible for depression.
Serotonin is a neurotransmitter that plays a key role in governing mood, sleep, digestion and other body functions. For years, a chemical imbalance of serotonin has been widely viewed as the culprit for depression, resulting in the widespread use of antidepressants like selective serotonin reuptake inhibitors (SSRIs), which boosts serotonin in the brain.