The scientists I talked to were less cautious about embracing this explanation than I expected. Down the hall from Skakkebæk's office, I met Anna-Maria Andersson, a biologist whose research has focused on declining testosterone levels. “There has been a chemical revolution going on starting from the beginning of the 19th century, maybe even a bit before,” she told me, “and upwards and exploding after the Second World War, when hundreds of new chemicals came onto the market within a very short time frame.” Suddenly a vast array of chemicals were entering our bloodstream, ones that no human body had ever had to deal with. The chemical revolution gave us some wonderful things: new medicines, new food sources, faster and cheaper mass production of all sorts of necessary products. It also gave us, Andersson pointed out, a living experiment on the human body with absolutely no forethought to the result.
When a chemical affects your hormones, it's called an endocrine disruptor. And it turns out that many of the compounds used to make plastic soft and flexible (like phthalates) or to make them harder and stronger (like Bisphenol A, or BPA) are consummate endocrine disruptors. Phthalates and BPA, for example, mimic estrogen in the bloodstream. If you're a man with a lot of phthalates in his system, you'll produce less testosterone and fewer sperm. If exposed to phthalates in utero, a male fetus's reproductive system itself will be altered: He will develop to be less male.
Women with raised levels of phthalates in their urine during pregnancy were significantly more likely to have sons with shorter anogenital distance as well as shorter penis length and smaller testes. “When the [fetus's] testicles start making testosterone, which is about week eight of pregnancy, they make a little less,” Swan said. “That's the nub of this whole story. So phthalates decrease testosterone. The testicles then do not produce proper testosterone, and the anogenital distance is shorter.”
The problem is that these chemicals are everywhere. BPA can be found in water bottles and food containers and sales receipts. Phthalates are even more common: They are in the coatings of pills and nutritional supplements; they're used in gelling agents, lubricants, binders, emulsifying agents, and suspending agents. Not to mention medical devices, detergents and packaging, paint and modeling clay, pharmaceuticals and textiles and sex toys and nail polish and liquid soap and hair spray. They are used in tubing that processes food, so you'll find them in milk, yogurt, sauces, soups, and even, in small amounts, in eggs, fruits, vegetables, pasta, noodles, rice, and water. The CDC determined that just about everyone in the United States has measurable levels of phthalates in his or her body—they're unavoidable.