Fortune 500 companies and longstanding corporate giants are losing to startups that are born digital because they can't keep up or they refuse to acknowledge the ways that technology is changing both business and consumer preferences. Getting "Ubered" is now one of the biggest threats to traditional IT departments as the growing number of unicorns like Airbnb, Spotify, Square, and others take over the economy and win the hearts and minds of increasingly mobile, always-on consumers. In this article, nine tech leaders from large companies talk about how they have had to change their approach in order to keep pace and avoid getting disrupted by the next big thing around the corner.