It's hard to say just one.
I think Crimson Desert has the potential to be the Witcher 3 of this generation in terms of open world rpgs. That to me makes it my most anticipated or I should say the one I'm most intrigued about and want to play.
GTA 6 is probably the one I'm most excited about. Requiem is the one I can't wait to play day one. I want to see how Phantom performs.
One thing for sure is this will absolutely be a banner year for gaming. I'm curious to see if a game like Clair comes out of the blue and steals the show.