Lansky was powerful, but he was by no means unique. Sam Giancana for example exceeded him in power and influence. He had his hands in many different pies across the world, including Iran.
Beyond that, Carlos Marcello, Santo Trafficante and Rusell Buffalino are 3 lesser known bosses that were probably even more powerful and dangerous than the Five Families or Chicago bosses.
Cosa Nostra during its peak was a very different animal than any criminal organization. It wasn't so much numbers(there were always big recruitment pools so number of "made guys" wasn't really important) as it was each boss' abilities and connections. Buffalino for instance was a big silent partner in Medico Industries, who was at one point the biggest supplier of munitions to the US. Think about that.
The old bosses were involved with the CIA in anti-Castro operations, had political power to the point where in certain states they were a shadow government, had a grip on entire industries, had control of the unions to the point where JFK/RFK feared they would shut down the entire country with a nationwide trucking strike. That's power, real power, which is even beyond money.
Criminal organizations today make more money(the big ones) because narcotics are the #1 moneymaker, but as far as real power and influence goes, no one will ever have what the 'guineas' once had. In America, not in a 3rd world country.