Plenty of people make a run for the hills all the time and disappear without a trace..the problem you're going to face is shyt planning or lack thereof when you're trying to disappear at the last minute. If you're not a hard-core planner in life you're done.
Trying to run without a preplanned execution set in motion years earlier won't yield results. First off you need to identify countries you could settle and blend in and where to actually go when you arrive, how to get out of the continental United States unseen, how to get all your money out discreetly and of course a new identity.
The best plan if you're Black is to move to a majority Black nation having learned the local language of the neighboring country beforehand so you slide in as a believable refugee. Even better if the place is poor with shyt communications infrastructure, so you can better stay off the grid. Bribe the officials for a local ID etc.
A breh from the Panthers bombed shyt in the US in the 70s or something and settled in Portugal. Told them he was an African immigrant, settled in got work and started a family and became a citizen. The feds caught wind few years back and demanded his extradition. Portugal said fukk that!
An Italian financial criminal fled Italy and ended up on an island off the coast of South America somewhere, where other fugitives had quietly fled and settled.
Opened up a record store selling vintage lps and stuff.
Now, he of course had a new identity and opened up a Facebook page with fake everything including birthday so he could talk to very close friends and family. Problem is they'would post happy birthday messages on his real birthday. Someone snitched, the cops took a look and placed an order for an original LP of The Girl From Ipanema which came with his finger prints all over it

And you know the rest of the story

They also bagged all the other Italian fugitives holed up in the island..
Most people would get caught because they can't lay low and stay off social media.