No Fap/Semen Retention Dangerous? (Why There Are Carcinogens in Your Sperm - Article)


Dec 11, 2015

Why There Are Carcinogens in Your Sperm​

Last week in this space, we recounted a few of the things that lower the risk of prostate cancer — from balding to espresso to cumming once a day. The cumming part especially interested us, for obvious reasons but also because of the reason why. Per a 2003 study conducted by Graham Giles, director of the Cancer Epidemiology Centre, men who ejaculated daily in their 20s were a third less likely to get prostate cancer later in life, since semen supposedly contains cancer-causing carcinogens (or the same kind of stuff you find on your grill char) and frequent clearing of the pipes may flush them out.

Or in more scientific-sounding terms: “It’s a prostatic stagnation hypothesis,” said Giles to the BBC. “The more you flush the ducts out, the less there is to hang around and damage the cells that line them.”

Giles added to New Scientist, “Also, the prostate, in the course of making seminal fluid, concentrates some powerful biological molecules to a very high degree to form that seminal fluid, and it’s a very reactive brew of ingredients. We feel that may be carcinogenic too.” Additionally, studies in dogs show that carcinogens such as 3-methylcholanthrene, a component of cigarette smoke, are concentrated in prostate fluid as well.

Furthermore, in 2006, researchers from the Medical Research Council’s Human Reproductive Sciences Unit at the University of Edinburgh discovered that the high concentration of prostaglandin — a hormone of sorts — in semen makes diseases of the female reproductive organs worse (including cervical and uterine cancer). While prostaglandin is naturally produced by the cells that line the female reproductive organs, the concentration of prostaglandin in seminal fluid is 1,000 times higher than that normally found in those cells. “Sexually active women who are at risk of cervical or uterine cancer should encourage their partners to wear a condom to prevent increased exposure to the prostaglandins that might make their condition worse,” lead researcher Henry Jabbour wrote.

Masturbation 'cuts cancer risk'

Men could reduce their risk of developing prostate cancer through regular masturbation, researchers suggest.

They say cancer-causing chemicals could build up in the prostate if men do not ejaculate regularly.

And they say sexual intercourse may not have the same protective effect because of the possibility of contracting a sexually transmitted infection, which could increase men's cancer risk.

Australian researchers questioned over 1,000 men who had developed prostate cancer and 1,250 who had not about their sexual habits.

They found those who had ejaculated the most between the ages of 20 and 50 were the least likely to develop the cancer.

The protective effect was greatest while the men were in their 20s.

Men who ejaculated more than five times a week were a third less likely to develop prostate cancer later in life.


Previous research has suggested that a high number of sexual partners or a high level of sexual activity increased a man's risk of developing prostate cancer by up to 40%.

But the Australian researchers who carried out this study suggest the early work missed the protective effect of ejaculation because it focussed on sexual intercourse, with its associated risk of STIs.

Graham Giles, of the Cancer Council Victoria in Melbourne, who led the research team, told New Scientist: "Had we been able to remove ejaculations associated with sexual intercourse, there should have been an even stronger protective effect of ejaculations."

The researchers suggest that ejaculating may prevent carcinogens accumulating in the prostate gland.

The prostate provides a fluid into semen during ejaculation that activates sperm and prevents them sticking together.

The fluid has high concentrations of substances including potassium, zinc, fructose and citric acid, which are drawn from the bloodstream.

But animal studies have shown carcinogens such as 3-methylchloranthrene, found in cigarette smoke, are also concentrated in the prostate.

'Flushing out'

Dr Giles said fewer ejaculations may mean the carcinogens build up.

"It's a prostatic stagnation hypothesis. The more you flush the ducts out, the less there is to hang around and damage the cells that line them."

A similar connection has been found between breast cancer and breastfeeding, where lactating appeared to "flush out" carcinogens, reduce a woman's risk of the disease, New Scientist reports.

Another theory put forward by the researchers is that ejaculation may induce prostate glands to mature fully, making them less susceptible to carcinogens.

Dr Chris Hiley, head of policy and research at the UK's Prostate Cancer Charity, told BBC News Online: "This is a plausible theory."

She added: "In the same way the human papillomavirus has been linked to cervical cancer, there is a suggestion that bits of prostate cancer may be related to a sexually transmitted infection earlier in life."

Anthony Smith, deputy director of the Australian Research Centre in Sex, Health and Society at La Trobe University in Melbourne, said the research could affect the kind of lifestyle advice doctors give to patients.

"Masturbation is part of people's sexual repertoire.

"If these findings hold up, then it's perfectly reasonable that men should be encouraged to masturbate," he said.

Ejaculation Changes Prostate Tissue, Lowering Cancer Risk.​

Higher frequency of ejaculation is associated with lower risk of prostate cancer, as a previous study led by a School of Public Health researcher confirmed.

Now, Jennifer R. Rider, assistant professor of epidemiology, and her colleagues have found a clue as to why, identifying molecular-level changes in prostate tissue.

The study, published in European Urology, finds evidence that more frequent ejaculation affects the expression of 409 genes and six biological processes. The study may support the “prostate stagnation hypothesis,” where carcinogens accumulate in the prostate between ejaculations and affect cells’ genome and metabolic processes.

“These molecular changes in the prostate persist for many years,” says Rider, who served as senior author on the study. “Understanding the biological links between ejaculation and prostate tumor development could lead to new behavioral or medical strategies for prevention.”

As in the previous study, the researchers used data from participants in the Health Professionals Follow-Up Study (HPFS), a prospective study of 31,925 men. This time, the researchers looked at the tumor tissue and adjacent normal prostate tissue of 157 participants who were diagnosed with prostate cancer between 1992 and 2004 and subsequently had part or all of their prostates removed. In 1992, participants had self-reported ejaculation frequency for when they were 20-29 years old, 40-49 years old, and in the previous year, 1991.

The researchers analyzed 20,254 genes in the samples, looking for relationships with different frequencies of ejaculation at different ages and times. They found no notable relationship between ejaculation frequency and gene expression in the tumor tissue. They also found no notable relationship between ejaculation frequency at ages 20-29 or 40-49 and gene expression. However, they found significant associations in the expression of 409 genes when they looked at ejaculation frequency in 1991.

Next, focusing on ejaculation frequency in 1991, the researchers found associations with six different biological processes at the cellular level. The most significant association was with ubiquitin-mediated proteolysis, which is involved in cell cycle regulation. The researchers also noted an association between higher rates of ejaculation and cells producing and exporting more citrate, a component of semen, because lower citrate production is a distinguishing feature of prostate cancer.

Rider notes the study used sample tissue only from men with a prostate cancer diagnosis. Next, she says, “we are interested in looking at whether expression of the genes and processes identified in the current study are able to predict future risk of prostate cancer development.”

The study’s lead author was Jennifer A. Sinnott of Ohio State University and the Harvard T.H. Chan School of Public Health. Other co-authors were: Katherine Brumberg of Yale University; and Kathryn M. Wilson, Ericka M. Ebot, Edward L. Giovannucci, and Lorelei A. Mucci of the Harvard T.H. Chan School of Public Health.

Does this prove doing no fap/semen retention is actually dangerous and unhealthy to do?? :lupe:


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Southern Chapter President of Broke Phi Broke
Apr 9, 2017
It’s funny how you always tag ya lil squad lmaoo..

but on topic, the issue is your body only being stimulated by only pornographic images/videos. Even amateur are being stimulated by watching another man pleasure a woman you find sexually attractive.. a man that looks like the average joe. That does something to your psyche. Remove pornography and you’re still repeatedly activating that blood rush done there.. add onto the fact if you have that death grip on it

you know how pathetic you look tryna jumpstart yourself in front of a relatively attractive woman?

:dame: ahead…
imagination > everything else. Also, using lotion & a slower stroke


Jun 22, 2013