naijaboi
All Star
Two hours just went by fast...great listen 
Tariq Nasheed going to be on Combat Jack
- Thread starter Busted_Toes
- Start date
Two hours just went by fast...great listen 
I thought the same thing but, it seems to be true just not the way it is told.
When we eat carbohydrates, and it's daytime, the tryptophan is converted to serotonin from the sunlight hitting our eyes. As the daytime turns to night, melatonin is synthesized from serotonin in the pineal gland. Once it enters the bloodstream, it goes to the skin where there are melanocytes. These melanocytes increase in numbers when there is more melatonin. The melanocytes then use tyrosine to make melanin. This means the more melatonin you create, the more melanin you will have. So it is true that ultimately it's the pineal gland that controls the rate of melanin you will have. Because melatonin, and melanin, is so good for you as far as health, and protection, it is no wonder that it is important to keep the pineal gland healthy and the ancients focused on it.
http://www.ncbi.nlm.nih.gov/pubmed/10965061
The effect of melatonin on melanocyte functions was studied by incubating whole-skin organ cultures with melatonin, as well as by assessing melatonin positivity in melanocytes versus dendricity and pigmentation, when arrested in the G(2) phase. From this study, it was observed that melatonin positivity is inversely related to the length of UV exposure. Increasing melatonin levels are related to decreasing dendricity and pigment donation during photoresponse in the G(2) phase. Melanocyte melatonin positivity increases with dark incubation and is higher with a pulse of UV exposure after dark incubation with melatonin. This increase is associated with a doubling of melanocyte number after dark incubation and a further doubling upon exposure to a pulse of UV. The melanocytes directly take up melatonin, which results in a marked increase in their numbers. Thus, extreme caution should be exercised when using melatonin as an anticancer drug. This finding also simulates the melanocyte repopulation of the skin with repigmentation during summer in polar animals.
Jone2three45
Superstar
I'm now going to debunk all of this.
Serotonin is derived from more sources than carbs and melatonin is derived from more sources than serotonin
False.
1. Melatonin does NOT go to your melanocytes. Thats just false.
2. Melanocytes DO NOT increase in number or have any effect on the amount of melatonin
2. Tyrosine isn't from a single source fam. Stop playing those games. Biochemistry isn't just single direct hand-waving pathways like that.
4. There is no link (in the literature) of any link between MELATONIN and MELANIN
5. The pineal gland has NO effect on the amount of melanin you have. The PITUITARY controls that. NOT THE PINEAL GLAND
OK...this is just more magic hand-waving bullshyt you're saying without understanding the terms you're using.
Melatonin affects sleep regulation
Melanin is pigmentation
And theres no connection between the two besides the names.
This article is not saying what you think its saying.
1. the pineal gland has light sensitive cells...thats not because its an "eye" but it has to sense certain wave lengths of light to know when to put your ass to sleeps.
2. the pineal gland only release melantonin when its super dark...so people who don't sleep well or in the dark have a problem with melatonin release.
3. Melanin blocks UV light (of certain wavelengths), clearly...
4. blocking certain types of light suggests that it'd be harder to regulate your melatonin regulation of pineal gland cells...IN VITRO...not in vivo. Big difference in trying pigmented cells in a dish and trying the same pathway in a living, breathing body with levels of regulation and control
5. OF COURSE it makes sense that if you give a HIGHER UV pulse (exposure to light) you get a negative pigmentation response... Thats what melanin is supposed to prevent...and with more light...the less melatonin! So whats the big deal! Melanin isn't special in this regard, its merely stopping UV light from affecting melatonin!
6. You also missed the major implication of this paper: MELATONIN MAY stimulate cancer proliferation....
I just tried to access the full paper and I can't even with my special login.
I'll just say this...
You don't understand what you read.
This was not suggesting that melatonin is in ANY way affecting melanocytes in any appreciable way....and even further in the way Tariq is suggesting.
I hear nothing more than science terms being used without any understanding of the science thats actually used to support these arguments.
You want to be right so bad, that you will just repeat what I wrote in other words!
1-Didn't I say the pineal gland produces serotonin in the daylight, and melatonin at night?
2-Same as above
3-Melanin doesn't block light it ABSORBS it.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671032/
" It has been traditionally believed that skin pigmentation is the most important photoprotective factor, since melanin, besides functioning as a broadband UV absorbent, has antioxidant and radical scavenging properties."
4-Again melanin ABSORBS light
5-Wrong AGAIN! The paper said the uv light pulse gave MORE melanocytes, NOT LESS. This means MORE PIGMENTATION.
6-You are adding to the paper! They say that because melatonin may increase tumor growth but, it's still questionable on whether it's from melatonin or something else. That's why they say to take precaution when TAKING it in pill form to PREVENT cancer. I noticed you skipped over the last sentence which goes against everything you wrote:
"This finding also simulates the melanocyte repopulation of the skin with repigmentation during summer in polar animals."
You are a fake and have no true love of science because if you did, you wouldn't be such a bullshyt artist, and would give up your old ways of thinking, when the truth is in your face.
I have no problem with this sentence, but you tried to link one source of a chemical while forgetting its endogenous pathways such as proteolysis or de-novo synthesis.
huh?
1. You gotta do better than scrawling pub-med for one-off articles. It takes a consensus to make a point, as well as sound data...so you're going to have to do more than read abstracts.
2. melanin BLOCKS certain wavelengths of light (UVB if I remember). I don't mean reflect. Theres a difference.
This changes nothing.
Which means melanin is reacting to light stimuli, as it should. This doesn't show anything.
And says NOTHING...read NOT A fukk!N THING about melatonin.
Maybe you can pick less shytty articles and try your luck on someone who doesn't have a masters, pushing professional degree.
I do this all day.
Hell, im in lab right now.
Yeah, you have no idea on the shyt you are speaking about at least in this case.
1-Damn near any scientist who studies the act of melanin will tell you melanin absorbs light. All dark pigments do. You are just going by the bullshyt being told for vitamin d. This tells me you really don't study how things in the body really work.
2-Again, it absorbs light.
3- No, the melanocytes is reacting to the light not melanin. The melanocyst are reacting to the melatonin this is why it states the amount of melanocytes DOUBLES when they recieved melatonin. This means a darker pigment ultimately.
4-You are really a dunce! The whole point was the melatonin increases the rate melanocytes, and increase pigmentation!.
You are so full of shyt. Anybody with some knowledge knows you are either being untruthful about your scientific degree or you are sitting in class not learning a damn thing, so you got by cheating. This shyt is elementary and you still can't put it together. WHAT A JOKE!
What bullshyt? That theres a crisis in the black community of vitamin D production at certain latitudes? Or that UVB absorption is best between 10a-3p? Cause I personally know one of the guys who is leading that research
And even further, i know it TECHNICALLY absorbs light, but the fact is that it dissipates UV light (specifically UV B) more than anything else.
Repeating bullshyt.
You fukking read the abstract and think you understood the whole paper.
Come.
The.
fukk.
On.
Even further, thats NOT what its saying (cause you don't even have or KNOW the mechanism, which is laughable since you seem to confuse the pituitary gland with the pineal gland, and confuse melanin with melatonin, and confuse WHERE either of them originate
EVEN. FU*KIN. FURTHER: It does not show how or why or even IF the melanocytes are "reacting" to the melatonin. I'm going to need more info before you go taking liberal license with summaries.
An increase in the number of melanocytes was not directly shown to be attributable BASED ON YOUR INFORMATION to administration of melatonin
Thats not what it said.
And the best you can do is liberally interpret a single paper that indirectly supports biochemical magic theory bullshyt just so you can sleep better at night.
If you're a fellow black man, you should be fukking ashamed of yourself for such intellectual dishonesty.
I already knew what level I was dealing with when you didn't even understand how the pituitary gland and pineal gland works, what their precursor polypeptide were, or how the biochemical pathways proceed.
Holler at me when you're doing trawling wikipedia and pick up a copy of your university's biochem textbook.
Better yet, give me your credentials and I'll give you a pass to the lab i'm in right now.
OK BUDDY!.
You know how I know you're bullshyt? You never explain how things work in detail, you always throw around some fake ass status you have, use words that you think others won't know or mean, and always claim you know someone or somewhere special. Only time people do that, is when they want you to believe their bullshyt. It's call hustling people. Some fall for it, but not me!
Maybe your ass needs to pay attention to the lab teacher instead of being on forums all day
You know how I know you're bullshyt? You never explain how things work in detail, you always throw around some fake ass status you have, use words that you think others won't know or mean, and always claim you know someone or somewhere special. Only time people do that, is when they want you to believe their bullshyt. It's call hustling people. Some fall for it, but not me!
Maybe your ass needs to pay attention to the lab teacher instead of being on forums all day
thank you for saying this. every time I see people mentioning the Pineal Gland & Melanin I just grit my teeth
it is a totally different gland that does that....neuromelanin is something that needs to be researched though
