Suction tackling - when running the ball, even if you run pass a good defensive player, they'll make you get sucked into himToo many things to list but:
Realistic foot planting and weight to stop, gliding and teleporting
Playbooks that reflect real life schemes especially defensively
The Oline needs major work
Weather having a real impact on the game and not just a visual thing
Better AI logic from play recognition to franchise scouting
Blocking A.I - especially on screen passes
fumble rate on mobile QBs that is much higher than real life
Tackling A.I on non controlled players (make them take intentionally bad angles to make good receivers/RBs look good)
basically, a lot of it has to do with scripted animations/lack of real time physics, AI. Along with the missing features from the PS2 era
The presentation is also a joke.