Women don't go by looks. They go by how you make them feel in person. You ugly gang dudes need to play into your strong suit which is personality, charisma, humor, and wit. Sending your pic & online dating is pointless.
I'd say they do, but it's probably not Game Over unless you look like the Deez Nuts nikka. Even then, someone out there could overlook your appearance and appreciate you. I honestly don't think anyone's doomed unless they just gave up and decided to be doomed.
I remember hearing from somewhere a quote that went along the lines of, "I don't believe in ugliness, but what I DO believe in, is laziness." And it makes sense. That's why people hit the gym, learn fashion and improve their hygiene. If you have all that in order, and provided your parent's genes are decent... You should be okay. Look at Kylie Jenner, perfect example.
But interacting in person is always going to be better off for people. Most people aren't good-looking to the point of having to put in absolutely no effort in getting to know somebody, so that's always the goal. Is being attractive going to help? Absolutely, that's a fact of life, but having charm, personality, humor and wit is gonna take you a lot further than somebody who doesn't. In fact, it's harder to have a strong personality than it would be to look attractive. At least for your appearance, most of it can either be bought or created in a gym, a complete personality overhaul is a whole other beast.