I hear it a lot TBH, been contracting for years and come across dudes with a Degree in CS but haven't heard or used AD, Exchange, SCCM and they tell me they found it hard to get a starting role as many hiring managers want experience of using those and your CV\resume prob wouldn't get noticed by recruitment agencies without those in your skillset.
Got a CS degree but never reset a users password in AD
Not to say its impossible, like I say I have worked alongside a few with CS degrees. And depends on the role your going for, but coming fresh outta of Uni with a CS degree with no experience of AD, Exchange, SCCM hiring managers would be like