Once we were in bondage, it was a wrap. There's no way you can defend yourself at that point, which is why Kanye's comment is so dumb.
As far as when they first came ashore to Africa, they had better technology and used divide and conquer tactics that defeated us. I think we underestimated how evil and cunning the cave devils were. By the time we realized what they were truly about, it was too late.
Slavery and Imperialism would still have occurred, but would have been a fraction of what it was, had there been more tribal alliances and collaboration to defeat the common foe.
But it happened, our ancestors paid the price, and hopefully we can learn from pain that they went through. It's gonna be a Herculean task to build our own societies and economies and escape the oppressive weight of White Supremacy, but that has to be the goal.