Not only does the blood relative thing help, like
@Peter Parker said, but Sha Money XL (50's manager and president of G-Unit Records in the 2000's) just did a podcast and was saying that 50 literally treated his artists with the framing of him a pimp to ho relationship. 50 looks at all interactions with the framing that there must be a winner and a loser. He doesn't have a cooperative personality type, and I don't think he's very good at moving in ways that are mutually beneficial for everyone.
Sha Money said it went back to his mom being a drug dealer, and hm viewing every relationship as a transactional affair, or an economical exchange. Sha even said he knew 50 would eventually burn his bridge with him too, and that he was always waiting for the shoe to fall, because that's just what 50 does.
50 is low key a sociopath.