career wise it's wade and it's not even close...
Right now, and prob the rest of there careers, it's manu and it is not even close...
You can run an an entire offense through manu...he can be your primary ball handler, he can be the guy coming off screens to get an open shot, he can be the guy cutting to the basket to finish. His shooting has been horrible, he has made just some straight up moronic decisions...but he has also gone through stretches where he ran the team flawlessly, and let's not act like he can't explode for 20 or more on any giving night...
Wade at this point is a borderline spot up shooter or just diving to the basket off a pick...he's not taking anyone off the dribble and his passing is not crisp enough to run your offense through him...
Really though it is a hard comparison because they are two different players doing two different things... Wade just had to eat off whatever scraps bron throws his way at this point....Manu is having to run a very sophisticated motion offense anytime parker goes to the bench, or anytime they run those gamut of screens for parker.