First Human Head Transplant Recipient Poised To Be Russian Man, Valery Spiridonov

[hoodheronova]

no bud
a brain with healthy vascularity can be sequentially bypassed vessell by vessel, for example you can feed the entire brain through the right anterior (carotid) and posterior (vertebrals) circulation before connecting the left side (the main vascular highway for this is the circle of willis). The areas of concerns, whenever one expects decreased perfusion to the brain, are what they call watershed areas, which are essentially fed by osmosis and do not have overlapping or particular anastomotic vessels.

the other option you have to keep in mind is that much of the surgery can be done and vascular changeover be left for the last step

I don't agree. If you bypass vessel by vessel you will trigger vasoconstriction in the areas less perfused leading to increased risk of stroke. Yes the circle of Willis provides collateral circulation, but not to the extent where you can bypass vessel by vessel. Maybe if you can maintain the CO2 throughout the brain, but I don't see that being possible

 

[tmonster]

I don't agree. If you bypass vessel by vessel you will trigger vasoconstriction in the areas less perfused leading to increased risk of stroke. Yes the circle of Willis provides collateral circulation, but not to the extent where you can bypass vessel by vessel. Maybe if you can maintain the CO2 throughout the brain, but I don't see that being possible

There is no reason i know of why you should expect a significant degree of vasoconstriction but you can prophylactically give vasodilators for that, it's practically an afterthought. And sequential or temporary bypasses used to be done routinely for endarterectomies of multiple vessel disease, this shyt is the least of their problems

 

[Black White Sox Hat]

It's finally happening..

 

[hoodheronova]

There is no reason i know of why you should expect a significant degree of vasoconstriction but you can prophylactically give vasolytics for that, it's practically an afterthought. And sequential or temporary bypasses used to be done routinely for endarterectomies of multiple vessel disease, this shyt is the least of their problems

You would expect a difference in vasoconstriction due to the physiological differences between parts of the brain receiving more blood flow compared to others leading to autoregulatory mechanism. Secondly, why would you give vasolytics while your doing vascular surgery, the patient is going to bleed out. No its not an afterthought. N please dont compare an endarterectomy to a complete transection of the cephalic blood flow, which are two different beasts.

 

[tmonster]

If you cut someone's head off

btw, this is too gross a term

but we can stop the conversation about plumbing and re-perfusion, by simply considering the issues of neuromapped autonomic innervation of the carotid body and sinus, the sympathetic chain and that of the great vessels, plumbing is the least of their problems and that is saying a lot

 

[tmonster]

You would expect a difference in vasoconstriction due to the physiological differences between parts of the brain receiving more blood flow compared to others leading to autoregulatory mechanism.

No part of the brain will simply not feed itself, that will never happen and autoregulation responding to your scenario leads to the opposite of what you are claiming

Secondly, why would you give vasolytics while your doing vascular surgery, the patient is going to bleed out. No its not an afterthought.

vasodilators is what I meant (I dited a little late, vasolytics would only apply to thrombosis concerns) but I was on my phone and driving so I had to wait till I could stop to edit. and yes in the grand scheme this is an afterthought of a concern that would have been easily worked out in animal experiments, way before human trials

N please dont compare an endarterectomy to a complete transection of the cephalic blood flow, which are two different beasts.

This is a gross and clumsy mischaracterization of my comment...ugh..

 

[Brosef]

no bud
a brain with healthy vascularity can be sequentially bypassed vessell by vessel, for example you can feed the entire brain through the right anterior (carotid) and posterior (vertebrals) circulation before connecting the left side (the main vascular highway for this is the circle of willis). The areas of concerns, whenever one expects decreased perfusion to the brain, are what they call watershed areas, which are essentially fed by osmosis and do not have overlapping or particular anastomotic vessels.

the other option you have to keep in mind is that much of the surgery can be done and vascular changeover be left for the last step

nothing worse than the coli pseudoscientists, almost worse than the militants

Carotids supply both the left and right anterior circulation

Verts supply the posterior

All of that is part of the circle of Willis, not the left side only

Supplying only the right first would cause a massive left sided stroke like what you see in a LMCA syndrome

And again, this doc is out of his mind

 

[Brosef]

There is no reason i know of why you should expect a significant degree of vasoconstriction but you can prophylactically give vasodilators for that, it's practically an afterthought. And sequential or temporary bypasses used to be done routinely for endarterectomies of multiple vessel disease, this shyt is the least of their problems

Endarterectomies are for severe asymptomatic or moderate symptomatic SINGLE vessel disease not for multiple vessel disease

 

[tmonster]

Endarterectomies are for severe asymptomatic or moderate symptomatic SINGLE vessel disease not for multiple vessel disease

no

 

[tmonster]

nothing worse than the coli pseudoscientists, almost worse than the militants

Carotids supply both the left and right anterior circulation

Verts supply the posterior

All of that is part of the circle of Willis, not the left side only

Supplying only the right first would cause a massive left sided stroke like what you see in a LMCA syndrome

And again, this doc is out of his mind

 

[hoodheronova]

i dont understand why you think the circle of Willis provides adequate collateral circulation in real life. Understand that real life doesnt = textbook. If it did then there would be far less strokes. Plus this doesnt even account for the lacunar arteries, which have poor collateral circulation. Not only that but if you did ECMO on the brain, you would increase the intracranial pressure to levels that are not safe.

 

[tmonster]

i dont understand why you think the circle of Willis provides adequate collateral circulation in real life. Understand that real life doesnt = textbook. If it did then there would be far less strokes. Plus this doesnt even account for the lacunar arteries, which have poor collateral circulation. Not only that but if you did ECMO on the brain, you would increase the intracranial pressure to levels that are not safe.

1. all this stuff is all about a textbook discussion, I was making an extreme point to support the plausibility of less demanding situation, sequential bypass
-the plumbing aspect of a head transplant can be practiced and worked out on primates, before the surgery of a human being
-my main point is that this is the easy part of their task
brosef is focusing on that and ignoring the main point
indications for endarcterectomy can be looked up, the principle idea is that patients have survived having their cervical/cephalic arteries bypassed temporarily

 

[The 2020 New Member]

I support this kind of nonsense.

 

[winb83]

This isn't real is it?

 

[Oztradamus]

This doctor is a......





































Wait for it....




































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A head case