Nas, Dre, Jay, LL, possibly Common, Possibly Ghost and Rae, maybe Eminem (debatable on what you thought of his comeback albums and guest appearances post 09), Juicy J, maybe Snoop depending on how you view his Pharell assisted albums. And from a producer standpoint Dre, Neptunes and Timbo
Anyone who fell off, has a good comeback album and run of good guest appearances again and other good album can probably constitute a multiple prime run especially if they reinvented themselves.
That might be pushing it but it depends on your viewpoint. Depends entirely on what you think a prime is.