I base a lot of my NFL bets on who will win in the trenches. That's where I think you can get the most value in betting spreads and totals because most of the time people really just focus on the star positions (QB, WR, RB).
Also, Mike Tomlin as a dog because he's the GOAT motivator.
That's exactly what my strategy is, a lot of money is moved during the live-play.