Breh, instead of looking at "numbers lost" look at "Ls collected". And the two ends of the spectrum are the Lannisters, with virtually none, and the Starks, with more than we can count.
One is seen as the protagonists, one is the antagonists. I don't mean in terms of their importance to the story, I mean their relation to each other.
Also don't look at numbers, look at who died. The Lannisters would have to lose Tywin for it to be equal to losing Ned....they'd have to lose Cersei for it to be equal to Catlyn....and even if it happened, that's 4 seasons that passed in the mean time.
As far as "the story isn't over"....I agree but this show has no idea how many season it will run for, and G.R.R. Martin could die before the books are done. So I'm looking at what we have right now. An article was just released today, saying the show will most likely run out of book material long before Martin is done, so that's an issue as well:
‘Game Of Thrones’ Can’t Wait For George R.R. Martin Anymore : MTV Proto
Fred.