They can make it open world and have Drake driving his jeep all around catching sheep and animals and have them those variations of climbing/slipping except divide them into missions. Have Sully create new weapons/utilities for capturing animals and other treasures and allow you to earn them by earning (insert country's currency).Meh, what else can they do with Uncharted's campaign that hasn't been done tho? I can only watch my character "almost" fall off a cliff only to have someone give a hand to grab, or a ledge to recover on for so long.

They can remove cutscenes for the most part and just give us a half assed story and cut it short by giving us a new chapter with remixed missions except Drake can't hang too long. Game will be 10/10 status and fans will defend it even though it's missing content.
Thank me later.