Respect really needs to be put on Higgs' name when it comes to best video game villains of all time.
I rarely felt a sense of "hate" seeing a character on screen like I did with Higgs. I wanted to see him dead.
I'm trying to think of villains that created that feeling before. I think Abbey from the last of us 2 when she killed Joel.
Characters like Sephiroth did terrible things but I never felt that sense of anger or hate towards them. Probably because he was cool as hell design wise and his story always had a sense of justifiable or understandable evil to an extent. I don't know. In any case, Higgs is a really well written villain.