There are a lot of things to be bummed about, especially if you're the type of person to be constantly looking toward the future (or even worse, stuck in the past). It's tough, but you gotta remain positive and find out how to live your best life in Babylon while hopefully not having a net negative effect on the world. A lot of trial and error. I can sympathize with being a misanthrop and nihilistic, but can't relate to actual depression or major depressive disorder. I dunno what that's about. Doing nice things for other people, exercising and eating half-way decent, and not keeping your head buried in a screen watching other people's lives can really go a long way. That much I do know. Life is too "loud" , being bombarded non stop with information, (bad) news, cultural psy-ops, and other people's opinions or other people's highlight reels... it's all noise. If you do things to turn the volume down you'll be much happier. At least that's what has worked for me. That, plus creative and physical outlets, keep me afloat.
It's interesting and inspiring to go to places like the DR or other countries where they don't have as much as us and watch how genuinely happy everyone is. there's a lot to learn from that, but at the same time that level of appreciation for basic life and being alive in general doesn't really mesh well with american society and babylon in general
ignorance is bliss too, to a large degree. if you're 18-35 just head over to reddit.com/r/lostgeneration and read some of the top posts... it will have the most blissfully positive Secret-quoting person in the world start looking like

in no-time