You're over complicating his entire point. It's not about independent vs. major...it's about making money vs. retaining ownership (as in publishing and masters) - in which MOST artist don't own either.
I believe his rant is to inspire and not just be used in music but in general. He just happens to personally apply it to music because it's his chosen profession.
If that's what its about that pretty much makes it independent vs major imo. How many of these dudes got the kinda stats where they can walk into a major and prove they can SELL a bunch of albums to where they can demand ownership?Nipsey tellin people they can do it all by themselves is great and I cosign and have already heard that and knew that,and every rapper knows that already. But is not that easy to be in a position that Nipsey is in. And frankly he owes part of the position he is in,and the relationships he has,and his name recognition to being on a major first....some people gon have to be in a ho position to make a name for theyself like Nipsey did,then they too can be in the position that he is in now.
I think its def inspiring for dudes who continuoulsy bump they head against a wall signing to major after major giving more and more of they power away with each move,just for the appearance of relevancy,and minor perks of a major that won't really benefit them. And also its inspiring for people in everyday walks of life too like u said.