It could work quite well...or it could be a dud exactly like Jordan Peele's Twilight Zone. (or Black Mirror seasons 4-6, though I liked this most recent season a lot)
With Coogler at the helm, I'd expect a multi-racial cast, possibly some LGBT members for spice...
But I'm not sure how you flip the basic concept of the show. - Mostly a Monster of the Week + Overarching Alien Conspiracy every couple of episodes.
In today's environment, the Network might do the series dirty, by trying to make it one overarching story, like how they played Sister Sonequa's Star Trek. On top of that, 6-10 episodes max, spaced out by multliple years....
So 1) vision for the series, 2) strength of the writing + Coogler's directing talents.
It's 1 & 2 that I'm most worried about.