Find what makes you happy and do it without a chance of anyone else interrupting that. Sounds simple, but it can be really difficult for some folks trying to take their mind off of being depressed, while they still saddled to other obligations and people that will temporarily derail them from achieving a comfortable centre to just enjoy yourself and being alive in the moment.
That's why I often turn off my phone when I need "Me" time so that I don't have to deal with anyone or anything and just chill. Out of all the drugs I've done, It's Ironic that the one I've avoided for so long, was the one to give me the best long lasting euphoric feeling that helps me to cope with when life's dragging me down and I can't shoulder the burden without lashing out, or fuming to the point of doing such.
Roll a joint, turn on some Reggae or some Cartoons and just chill, alone or in the lap of an agreeable female and just forget what's ailing me for a moment and let my mind wander. Outside of smoking weed through Grief, I've never not toked some herb and failed to feel good during and afterwards.
Also, taking a bath and drinking a cold glass of water really helps me too, but then again I'm often dirty and dehydrated at times, so maybe I'm just appreciating going back to normal rather then finding some sort of weird comfort from it...but then again I'm a pretty weird guy, so there's that too.