Yes he does. He has more influence over
1. E-40 than E-40 has over anyone. Nobody sounds like E-40.
2. E-40 signed Nef the Pharoah - who is a repackaged Mac Dre for the youth. That, in itself, is 1 rapper more than you can point to as having been influenced than E-40
3. E-40 is not culturally influential to the extent that Mac Dre is.
Mac Dre is stylistically more influential , and MUCH more CULTURALLY influential than E-40 is. This is rather self-evident if you have basic standards in you assessment for cultural influence